Area of Research

• Research in the Lombard Lab focuses on identifying and targeting the mechanisms of prostate tumor progression, with the goal of enhancing therapeutic efficacy and designing novel strategies to improve patient outcomes. The clinical landscape for the management of prostate cancer is rapidly changing. Next-generation anti-androgens have significantly improved androgen receptor targeting, and the addition of novel agents, including PARP inhibitors, has greatly augmented our ability to treat advanced disease. Despite this progress, patients still progress. We employ a multi-pronged strategy including 1) development and utilization of in vitro and in vivo models, 2) molecular/cellular biological, biochemical, and omics approaches, and 3) bioinformatics to understand the underlying mechanisms of tumor biology and response and resistance to therapy. Our goal is to incorporate novel findings into the design of efficacious treatments.